An adult with gout is starting allopurinol for long-term urate-lowering therapy. Which initiation strategy is recommended in UK practice?...

Question

An adult with gout is starting allopurinol for long-term urate-lowering therapy. Which initiation strategy is recommended in UK practice?

Accepted Answer

Start 100 mg once daily (less in severe renal impairment), then titrate using serum urate.

Answer

Start 300 mg once daily, then continue at that dose for 6 months.

Answer

Start 200 mg twice daily, then reduce only if adverse effects occur.

Answer

Start 50 mg on alternate days for every patient, then review annually.

Answer

Start the estimated maintenance dose, then monitor only if symptoms recur.

Allopurinol-Initiation Strategy — PSA MCQ