NSAID-Related Ulcer Prophylaxis — MRCP Part 1 MCQ

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MediumGastroenterologyNSAID-Related Ulcer ProphylaxisMRCP Part 1

A 58-year-old with prior ulcer bleed on aspirin for secondary prevention now needs NSAID therapy. What GI protection strategy is recommended?

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Correct answer: D — Add a PPI while using NSAIDs and continue aspirin

Patients requiring NSAIDs with high GI risk should receive PPI co-therapy; continue necessary secondary-prevention aspirin. H2-blockers are less protective for ulcer prevention. Switching to clopidogrel does not address NSAID risk. Stopping necessary aspirin may increase CV risk.

Reference: ACG Guideline (2022)