Question

A 60-year-old with HFrEF on lisinopril is being switched to sacubitril/valsartan. What timing is required?

Accepted Answer

Start after a 36-hour washout

Answer

Start sacubitril/valsartan immediately after last ACE inhibitor dose

Answer

Start after a 12-hour washout

Answer

Start only after potassium <4.0 mEq/L

Answer

Continue ACE inhibitor with ARNI overlap for 24 h

Practice question

A 60-year-old with HFrEF on lisinopril is being switched to sacubitril/valsartan. What timing is required?