Question

A 37-year-old with major depressive disorder, no prior treatment, moderate severity, and no suicidality seeks therapy. Which initial treatment is guideline-concordant?

Accepted Answer

Second-generation antidepressant (e.g., SSRI/SNRI/bupropion/mirtazapine) or CBT as monotherapy

Answer

Tricyclic antidepressant as first choice in all

Answer

Start MAOI with tyramine-restricted diet

Answer

Antipsychotic monotherapy

Answer

ECT as first-line

Practice question

A 37-year-old with major depressive disorder, no prior treatment, moderate severity, and no suicidality seeks therapy. Which initial treatment is guideline-concordant?