Question

A 57-year-old hospitalized patient develops nonsevere, first-episode Clostridioides difficile infection (WBC 11,000/µL, creatinine normal). What is the preferred initial antibiotic regimen?

Accepted Answer

Oral fidaxomicin 200 mg twice daily for 10 days

Answer

Oral metronidazole 500 mg three times daily for 10 days

Answer

Oral vancomycin 125 mg four times daily for 10 days is strongly preferred

Answer

Bezlotoxumab monotherapy

Answer

IV piperacillin-tazobactam for 10 days

Practice question

A 57-year-old hospitalized patient develops nonsevere, first-episode Clostridioides difficile infection (WBC 11,000/µL, creatinine normal). What is the preferred initial antibiotic regimen?