Question

A 73-year-old with nonvalvular AF on apixaban 5 mg bid has AIS 2 hours after onset. CT is negative for hemorrhage. Which statement is most accurate regarding IV alteplase?

Accepted Answer

Alteplase is contraindicated if a DOAC was taken within 48 h unless coagulation testing indicates no drug effect

Answer

Alteplase can be given because onset <3 h

Answer

Give DAPT then alteplase

Answer

Give tenecteplase because DOAC use is irrelevant

Answer

Wait 24 h then give alteplase

Practice question

A 73-year-old with nonvalvular AF on apixaban 5 mg bid has AIS 2 hours after onset. CT is negative for hemorrhage. Which statement is most accurate regarding IV alteplase?