Question

A 42-year-old with first episode of nonsevere Clostridioides difficile infection (WBC 10,000/µL, creatinine normal) and no prior CDI presents with ≥3 unformed stools/day. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg orally twice daily for 10 days

Answer

Metronidazole 500 mg orally three times daily for 10 days

Answer

Vancomycin 125 mg orally four times daily for 10 days

Answer

Bezlotoxumab monotherapy

Answer

Fecal microbiota transplant now

Practice question

A 42-year-old with first episode of nonsevere Clostridioides difficile infection (WBC 10,000/µL, creatinine normal) and no prior CDI presents with ≥3 unformed stools/day. Best initial therapy?