Question

A 52-year-old with first episode of nonsevere C. difficile infection (WBC 10,800/µL; creatinine normal) has no prior CDI. Best initial therapy?

Accepted Answer

Fidaxomicin 200 mg twice daily for 10 days (preferred)

Answer

Metronidazole 500 mg TID for 10 days

Answer

Oral vancomycin 125 mg QID for 10 days (preferred)

Answer

Oral vancomycin taper/pulse

Answer

Fecal microbiota therapy

Practice question

A 52-year-old with first episode of nonsevere C. difficile infection (WBC 10,800/µL; creatinine normal) has no prior CDI. Best initial therapy?