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HardHaematologyPrimary Myelofibrosismrcp part 1ukmla

A 60-year-old woman presents with fatigue and shortness of breath. FBC shows pancytopenia (low Hb, WCC, and Platelets). Blood film shows teardrop poikilocytes and nucleated red blood cells (leukoerythroblastic picture). On examination, she has massive splenomegaly. Bone marrow biopsy reveals fibrosis. What is the most likely diagnosis?

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