Question

A 30-year-year-old man presents with chronic diarrhoea and bloating. He reports fatigue and mouth ulcers. Blood tests show microcytic anaemia (Hb 100 g/L, MCV 75 fL). IgA Tissue Transglutaminase (anti-tTG) antibodies are strongly positive. What is the definitive diagnostic investigation?

Accepted Answer

Oesophagogastroduodenoscopy (OGD) and duodenal biopsy

Answer

Colonoscopy and biopsy

Answer

Hydrogen breath test

Answer

Small bowel MRI

Answer

Trial of gluten-free diet

Practice question

A 30-year-year-old man presents with chronic diarrhoea and bloating. He reports fatigue and mouth ulcers. Blood tests show microcytic anaemia (Hb 100 g/L, MCV 75 fL). IgA Tissue Transglutaminase (anti-tTG) antibodies are strongly positive. What is the definitive diagnostic investigation?