Question

A 75-year-old man with a longstanding diagnosis of benign prostatic hyperplasia (BPH) is prescribed amitriptyline for neuropathic pain. A week later he presents with acute, painful urinary retention. What is the mechanism by which amitriptyline caused this?

Accepted Answer

Anticholinergic effects

Answer

Alpha-1 adrenergic blockade

Answer

Dopamine antagonism

Answer

Serotonergic effects

Answer

Opioid receptor agonism

Practice question

A 75-year-old man with a longstanding diagnosis of benign prostatic hyperplasia (BPH) is prescribed amitriptyline for neuropathic pain. A week later he presents with acute, painful urinary retention. What is the mechanism by which amitriptyline caused this?