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HardNeurologyMotor Neurone Disease (MND)mrcp part 1ukmlapane

A 68-year-old man presents with progressive weakness of his limbs over several months. He reports muscle twitching and cramps. On examination, there is wasting of the small muscles of the hands, fasciculations in the arms and legs, brisk reflexes in all limbs, and extensor plantar responses. Sensation is normal. What is the most likely diagnosis?

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