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MediumPharmacologyAdverse Drug Reaction (Amitriptyline and Urinary Retention)ukmlamrcgp aktpaneprescribing safety assessmentmrcem sba

A 77-year-old man with a history of benign prostatic hyperplasia (BPH) is prescribed amitriptyline 25mg at night for neuropathic pain by his GP. Two weeks later, he presents to the Emergency Department with acute, painful urinary retention. Which pharmacological property of amitriptyline is most likely responsible for this adverse effect?

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