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MediumRespiratory MedicineAcute Severe Asthmaukmlamrcem sbamrcp part 1paneprescribing safety assessment

A 25-year-old known asthmatic presents to the Emergency Department with acute shortness of breath and wheeze. Her peak expiratory flow rate (PEFR) is 45% of her best. She is speaking in short sentences. Oxygen saturation is 93% on air. According to BTS/SIGN guidelines, what is the most appropriate initial pharmacological management in addition to high-flow oxygen?

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