Question

A 70-year-old patient is taking Apixaban 5mg BD for atrial fibrillation. They are prescribed Clarithromycin 500mg BD for a chest infection. What is the potential interaction and recommended action according to the BNF?

Accepted Answer

Increased risk of bleeding; avoid combination or use alternative antibiotic

Answer

Increased risk of bleeding; reduce Apixaban dose

Answer

Decreased Apixaban effect; increase Apixaban dose

Answer

Increased risk of myopathy; monitor CK levels

Answer

No significant interaction; continue both medications as prescribed

Practice question

A 70-year-old patient is taking Apixaban 5mg BD for atrial fibrillation. They are prescribed Clarithromycin 500mg BD for a chest infection. What is the potential interaction and recommended action according to the BNF?