MediumHaematologyChronic Myeloid Leukaemia (CML)mrcp part 1ukmla
A 60-year-old man presents with a 6-month history of fatigue, weight loss, night sweats, and abdominal discomfort due to fullness. Examination reveals significant splenomegaly extending below the umbilicus. Full blood count shows: Hb 95 g/L, WCC 150 x10^9/L, Platelets 550 x10^9/L. The blood film report notes a marked left shift with presence of myelocytes, metamyelocytes, and occasional blasts. Cytogenetic analysis is pending but likely to show the Philadelphia chromosome. What is the most likely diagnosis?