Question

A 68-year-old patient with a 35-year smoking history presents with progressive dyspnoea and chronic cough. Spirometry shows an FEV1/FVC ratio of 0.6. According to NICE guidelines, which is the most appropriate first-line pharmacological therapy for stable COPD with no asthmatic features?

Accepted Answer

Short-acting beta-2 agonist as needed

Answer

Long-acting muscarinic antagonist (LAMA)

Answer

High-dose inhaled corticosteroid

Answer

Long-acting beta-2 agonist (LABA) plus inhaled corticosteroid

Answer

Roflumilast

Practice question

A 68-year-old patient with a 35-year smoking history presents with progressive dyspnoea and chronic cough. Spirometry shows an FEV1/FVC ratio of 0.6. According to NICE guidelines, which is the most appropriate first-line pharmacological therapy for stable COPD with no asthmatic features?