Question

A 38-year-old woman with type 2 diabetes mellitus on metformin has an HbA1c of 62 mmol/mol (7.8%). According to NICE guidelines, which is the most appropriate second-line therapy to add?

Accepted Answer

Sulfonylurea (e.g., gliclazide)

Answer

Insulin glargine

Answer

Glucagon-like peptide-1 (GLP-1) agonist

Answer

Dipeptidyl peptidase-4 (DPP-4) inhibitor (e.g., sitagliptin)

Answer

Immediately start combination insulin therapy

Practice question

A 38-year-old woman with type 2 diabetes mellitus on metformin has an HbA1c of 62 mmol/mol (7.8%). According to NICE guidelines, which is the most appropriate second-line therapy to add?