Intensity-modulated radiotherapy (IMRT) does provide advantages in reducing local skin effects, including acute radiation dermatitis, in patients undergoing radiotherapy for breast cancer. The UK guideline NICE NG101 recommends using radiotherapy techniques that minimise dose to surrounding organs, such as the lung and heart, to reduce side effects, and IMRT is specifically noted to reduce acute erythema by improving dose homogeneity at the skin surface compared with three-dimensional conformal radiotherapy NICE NG101,Burke et al. 2026 Siedlecki et al. 2026.
Although radiotherapy carries risks of short- and long-term adverse effects on the breast—such as skin soreness, colour changes, radiation fibrosis, and breast tissue stiffening—modern conformal techniques like IMRT and volumetric-modulated arc therapy (VMAT) help mitigate these effects by delivering more precise doses and sparing normal tissues NICE NG101,Burke et al. 2026.
Chronic radiation dermatitis (CRD), characterized by fibrosis, telangiectasia, pigmentation changes, and skin atrophy, manifests months to years post-radiotherapy, occurring in approximately one-third of patients, often with significant quality-of-life impact Burke et al. 2026,Siedlecki et al. 2026. IMRT and techniques such as VMAT reduce both acute and late cutaneous toxicities by decreasing hot spots within the breast and improving dose conformity NICE NG101,Burke et al. 2026 Siedlecki et al. 2026.
In the context of a patient with high-grade ductal carcinoma in situ measuring 8 mm and a small invasive ductal carcinoma of 3 mm with clear margins, node-negative and no additional microcalcifications, the likelihood of local recurrence is low, but radiotherapy may still be considered after breast-conserving surgery to further reduce this risk NICE NG101. IMRT offers a more tailored approach that reduces the incidence and severity of radiation-induced skin toxicities compared with older techniques NICE NG101,Burke et al. 2026.
Therefore, for right-sided breast cancer patients in this low-risk scenario, IMRT can reduce acute skin side effects like dermatitis, leading to better cosmetic outcomes and patient comfort, while maintaining efficacy in tumor control NICE NG101,Burke et al. 2026. However, long-term data specifically comparing chronic skin fibrosis between techniques are limited, and some late skin changes may still occur despite technological advances Burke et al. 2026,Siedlecki et al. 2026.
Careful planning to avoid unnecessary high-dose exposure to skin and underlying organs is critical in all breast radiotherapy, with techniques like deep inspiratory breath-hold recommended particularly for left-sided cancers to reduce cardiac dose, but IMRT benefits in skin toxicity apply broadly NICE NG101.
Key References
- NICE NG101: Early and locally advanced breast cancer: diagnosis and management
- SmPC: Doxorubicin 2 mg/ml Concentrate for solution for infusion
- SmPC: Tamoxifen 10mg Film-Coated Tablets
- SmPC: Tamoxifen 20mg Film-Coated Tablets
- NICE CKS: Palliative care - malignant skin ulcer
- (Sang et al., 2026): Rapid Hemostasis and Significant Tumor Regression in Ulcerative Breast Cancer Via Combined Modified Lattice Radiotherapy and Systemic Therapy: A Case Report.
- (Burke et al., 2026): Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.
- (Siedlecki et al., 2026): Chronic radiation-induced dermatitis: what is new in 2024? A narrative review.