Is there any interaction between omeprazole and a raised hbA1c

Clinical answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 11 December 2025Updated: 11 December 2025 Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

There is no direct evidence or documented interaction between omeprazole and elevated hemoglobin A1c (HbA1c) levels in the provided UK clinical guidelines and summaries. Omeprazole, a proton pump inhibitor, is primarily noted for its effects on gastric acid suppression and potential interactions with other drugs, but no specific impact on glycemic control or HbA1c has been reported in the referenced materials.

While proton pump inhibitors like omeprazole require monitoring for serum magnesium during prolonged use, no mention is made of effects on blood glucose or HbA1c levels.

Therefore, based on current UK guideline excerpts, omeprazole does not have a recognized interaction with elevated HbA1c levels.

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