Recommended mx for acute sinusitis in primary care, including when to prescribe

Clinical answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 23 November 2025Updated: 23 November 2025 Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Recommended management for acute sinusitis in primary care:

  • Most cases of acute sinusitis are viral and self-limiting, resolving within 12 weeks without antibiotics. Advise patients that bacterial sinusitis is usually self-limiting and does not routinely require antibiotics.
  • Offer symptomatic treatment with paracetamol or ibuprofen for pain or fever relief.
  • Consider nasal saline irrigation or nasal decongestants for nasal congestion, although evidence for their effectiveness is limited.
  • For adults and children aged 12 years and over, a high-dose nasal corticosteroid (e.g., mometasone 200 micrograms twice daily for 14 days) may be considered to improve symptoms, but it is unlikely to shorten illness duration.
  • Do not routinely prescribe oral corticosteroids, oral decongestants, antihistamines, mucolytics, steam inhalation, or warm face packs as these are not recommended due to lack of evidence of benefit.
  • Antibiotic prescribing guidance:
    • Do not routinely prescribe antibiotics for acute sinusitis.
    • Consider a back-up (delayed) antibiotic prescription if symptoms persist beyond 10 days, or if there is a marked deterioration after an initial milder phase ("double sickening"), or if symptoms are severe (e.g., fever >38°C, severe localized unilateral pain, discoloured or purulent nasal discharge).
    • Immediate antibiotic prescription is reserved for patients who are systemically very unwell, have signs of a more serious illness, or are at high risk of complications due to comorbidities or immunosuppression.
    • If antibiotics are indicated in adults, phenoxymethylpenicillin 500 mg four times daily for 5 days is the first-line treatment.
    • Advise patients given a back-up antibiotic to start it only if symptoms do not improve within 7 days or worsen rapidly or significantly at any time.
    • Reassess patients if symptoms worsen rapidly or significantly despite treatment, considering alternative diagnoses and referral to specialists if needed.

Provide written advice and safety-netting information, including when to seek further medical help if symptoms worsen or do not improve after 3 weeks.

This approach balances effective symptom management with antimicrobial stewardship to reduce unnecessary antibiotic use and adverse effects.

References: ,

Educational content only. Always verify information and use clinical judgement.

Recommended mx for acute sinusitis in primary care, including when to