Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX
Causes of Failure to Thrive (Faltering Growth) in Children
- Faltering growth in children can result from a complex interplay of factors including inadequate nutritional intake, feeding difficulties, underlying medical conditions, and psychosocial issues. Common associated factors include preterm birth, neurodevelopmental concerns, maternal postnatal depression or anxiety, and feeding aversion or ineffective feeding techniques (e.g., ineffective suckling or bottle feeding) NICE NG75.
- Underlying medical causes may include gastrointestinal disorders such as coeliac disease or inflammatory bowel disease, infections like urinary tract infections, and malabsorption syndromes Pucinischi et al. 2025Wong et al. 2021 NICE NG75.
- In some cases, failure to thrive may be multifactorial with no single clear cause, and difficulties in parent-child feeding interactions may contribute but not be the primary cause NICE NG75.
Diagnostic Approaches
- Diagnosis begins with careful measurement and plotting of weight, length (under 2 years), or height (over 2 years) on UK WHO growth charts to identify faltering growth, defined by specific centile falls depending on birthweight and current weight centiles NICE NG75.
- Clinical, developmental, and social assessments are essential, including detailed feeding and eating histories and, where appropriate, direct observation of feeding or mealtimes by trained professionals NICE NG75.
- Investigations should be guided by clinical findings; routine extensive investigations are not recommended in well-appearing children without other clinical concerns. Targeted investigations may include screening for urinary tract infection, coeliac disease, and other relevant conditions based on history and examination NICE NG75.
- Additional assessments may include calculating BMI centiles in children over 2 years to assess for undernutrition and considering parental heights to evaluate growth potential NICE NG75.
- Keeping a food and mealtime diary can help identify feeding patterns, food intake, and behavioural issues contributing to faltering growth NICE NG75.
- In cases of suspected malabsorption or inflammatory bowel disease, further specialist investigations and nutritional assessments are warranted, as these conditions can cause growth delay and nutrient deficiencies Wong et al. 2021Pucinischi et al. 2025 NICE NG75.
Management Strategies
- Management should be multidisciplinary, involving paediatricians, dietitians, infant feeding specialists, speech and language therapists, psychologists, and occupational therapists as needed, coordinated by a lead healthcare professional NICE NG75.
- Feeding support is critical, especially in the early weeks of life, with encouragement of relaxed, enjoyable feeding and mealtimes, family eating, self-feeding in young children, and avoidance of coercive or punitive feeding practices NICE NG75.
- Parents should be supported with clear, specific information tailored to their child’s needs, including advice on appropriate food types, textures, and nutrient density to optimize energy intake NICE NG75.
- Supplementary feeding with infant formula may be considered in breastfed infants with faltering growth but should be accompanied by support to continue breastfeeding and promote milk supply through expressing breast milk NICE NG75.
- For children with continuing faltering growth despite dietary advice, short-term dietary fortification with energy-dense foods or oral liquid nutritional supplements prescribed by a paediatric dietitian may be beneficial NICE NG75.
- Enteral tube feeding is reserved for severe cases with serious concerns about weight gain after thorough multidisciplinary assessment and failure of other interventions NICE NG75.
- Regular monitoring of growth, feeding tolerance, and adherence to interventions is essential to assess progress and adjust management plans accordingly NICE NG75.
- In children with underlying inflammatory bowel disease or malabsorption, management includes addressing the primary disease, monitoring for nutritional deficiencies, and supporting growth and pubertal development Wong et al. 2021 NICE CKS.
Key References
- NG75 - Faltering growth: recognition and management of faltering growth in children
- CKS - Faltering growth
- CKS - Ulcerative colitis
- Sodium benzoate SmPC
- Sodium phenylbutyrate SmPC
- Citrulline SmPC
- Pyridoxine hydrochloride SmPC
- Sapropterin dihydrochloride SmPC
- Co-phenotrope SmPC
- (Wong et al., 2021): Growth Delay in Inflammatory Bowel Diseases: Significance, Causes, and Management.
- (Pucinischi et al., 2025): Enhancing pediatric practice: A comprehensive review on malabsorption in pediatrics for diagnostic and management approach.