Contraindications for medroxy progesterone

Contraindications for the use of medroxyprogesterone acetate include:

• General contraindications: acute porphyrias and current breast cancer (unless progestogens are being used in the management of this condition).
• Specific contraindications with oral use: history of thromboembolism and undiagnosed vaginal bleeding.
• When used for contraception: current or history of meningioma.

High-dose medroxyprogesterone acetate (all parenteral preparations and oral preparations containing 100 mg or more) is contraindicated in patients with meningioma or a history of meningioma; if meningioma is diagnosed during treatment, the drug must be stopped.

These contraindications are based on safety concerns including thromboembolic risk, cancer risk, and undiagnosed bleeding that may indicate underlying pathology.

References: Products