When should a patient with suspected cryoglobulin-associated vasculitis be referred urgently to a specialist?

Patients with suspected cryoglobulin-associated vasculitis should be referred urgently to a specialist if they present with systemic symptoms such as fever, night sweats, weight loss, or unexplained lymphadenopathy or splenomegaly. These features may indicate severe or systemic involvement requiring prompt specialist assessment.

Although the provided guidelines focus primarily on suspected cancer referrals, the presence of systemic symptoms like fever, night sweats, pruritus, weight loss, lymphadenopathy, or splenomegaly are highlighted as triggers for very urgent referral (within 48 hours) for specialist assessment in related conditions, which can be extrapolated to serious vasculitis cases including cryoglobulin-associated vasculitis.