What are the recommended fluid resuscitation protocols for managing hypovolemic shock in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Recommended fluid resuscitation protocols for managing hypovolemic shock in adult patients:

  • Initial assessment should identify hypovolemia using clinical indicators such as systolic blood pressure less than 100 mmHg, heart rate over 90 bpm, capillary refill time over 2 seconds or cold peripheries, respiratory rate over 20 breaths per minute, and a National Early Warning Score (NEWS) of 5 or more. Passive leg raising can be used to assess fluid responsiveness at the bedside .
  • For fluid resuscitation, intravenous (IV) fluids should be administered promptly to patients who cannot meet their fluid needs orally or enterally, with continuous reassessment and monitoring .
  • In cases of hypovolemic shock due to active bleeding (haemorrhagic shock), hospital protocols recommend avoiding crystalloids and instead using blood components with a ratio of 1 unit plasma to 1 unit red blood cells for adults .
  • In pre-hospital settings, crystalloids may be used to replace fluid volume if blood components are unavailable, but in hospital settings, blood components are preferred for active bleeding .
  • For non-bleeding hypovolemic shock, follow the NICE guideline on intravenous fluid therapy in adults, which includes using isotonic crystalloid solutions for initial resuscitation, titrated to clinical response and ongoing monitoring .
  • Continuous monitoring during resuscitation should include ABCDE assessment, respiratory rate, pulse, blood pressure, perfusion, venous lactate, arterial pH, and base excess as per advanced life support guidance .
  • Fluid prescriptions must specify type, rate, and volume, and patients should have an IV fluid management plan with daily expert review initially .

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