What are the key clinical features that should raise suspicion for a bone or soft tissue sarcoma in a patient?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Key clinical features raising suspicion for bone or soft tissue sarcoma include:

  • An unexplained lump that is increasing in size, particularly in children and young people, which should prompt consideration of soft tissue sarcoma and urgent ultrasound within 48 hours.
  • Persistent or unexplained bone pain in children and young people, which should raise suspicion of bone sarcoma and prompt urgent X-ray within 48 hours.
  • In adults, an X-ray suggesting the possibility of bone sarcoma warrants a suspected cancer pathway referral.

These features should be considered alongside any associated symptoms such as weight loss, fever, or night sweats, which may further support the need for urgent referral.

Educational content only. Always verify information and use clinical judgement.