What are the current NICE guidelines for the use of PSA testing in asymptomatic men?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

NICE guidelines do not recommend routine prostate-specific antigen (PSA) testing in asymptomatic men. PSA testing should be considered only after informed discussion and shared decision-making, particularly if men have lower urinary tract symptoms (LUTS) suggestive of bladder outlet obstruction, an abnormal digital rectal examination, or concerns about prostate cancer.

Specifically, men with LUTS should be offered information, advice, and time to decide if they wish to have PSA testing when their symptoms suggest benign prostate enlargement or if their prostate feels abnormal on examination.

There is no recommendation to screen asymptomatic men without these indications using PSA testing in primary care.

Educational content only. Always verify information and use clinical judgement.