What are the recommended pharmacological treatments for postpartum psychosis, and how do they differ from those for postpartum depression?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Pharmacological treatments for postpartum psychosis typically involve the use of antipsychotic medications, which are considered first-line treatment, especially in severe cases .

In addition, mood stabilisers such as lithium may be used, but with caution due to potential risks during breastfeeding and pregnancy .

Electroconvulsive therapy (ECT) is also considered for severe cases, particularly when rapid response is needed or medication is contraindicated .

Pharmacological treatments for postpartum depression generally include antidepressants, primarily selective serotonin reuptake inhibitors (SSRIs), which are preferred due to their safety profile and efficacy .

Psychotropic medication should be chosen with consideration of the lowest risk profile for the woman, fetus, and baby, and dosages should be carefully adjusted .

In summary, postpartum psychosis treatment emphasizes antipsychotics and mood stabilisers, whereas postpartum depression primarily involves antidepressants, with treatment tailored to the severity and individual circumstances .

Educational content only. Always verify information and use clinical judgement.