How should I manage a patient with an ABG showing severe hypoxemia and

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Management of a patient with severe hypoxemia and hypercapnia on arterial blood gas:

Assess the patient urgently for the need for hospital admission, as severe hypoxemia (PaO2 <7 kPa) and hypercapnia indicate respiratory failure requiring close monitoring and treatment in hospital .
Administer controlled oxygen therapy carefully to correct hypoxemia while avoiding worsening hypercapnia; oxygen saturation targets should be individualized, often aiming for 88-92% in COPD patients to prevent CO2 retention .
Consider non-invasive ventilation (NIV) promptly if the patient is acidotic or has persistent hypercapnia despite optimal medical treatment, as NIV reduces mortality and the need for invasive ventilation .
Evaluate for and treat underlying causes such as COPD exacerbation, infection, or other respiratory pathology with appropriate antibiotics, bronchodilators, and corticosteroids as indicated .
Monitor arterial blood gases intermittently to assess response to treatment until the patient is stable .
Assess suitability for invasive ventilation if NIV fails or if the patient deteriorates, considering functional status, comorbidities, and previous ICU admissions .

How should I manage a patient with an ABG showing severe hypoxemia and hypercapnia?