How should I manage a patient with mild OHSS in a primary care setting?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Management of mild ovarian hyperstimulation syndrome (OHSS) in primary care:

  • Recognise mild OHSS by symptoms such as abdominal discomfort, mild abdominal distension, nausea, and mild ovarian enlargement without significant complications.
  • Advise conservative management including adequate oral hydration and rest.
  • Monitor symptoms closely and advise the patient to seek urgent medical attention if symptoms worsen, such as increasing abdominal pain, vomiting, rapid weight gain, or breathlessness, which may indicate progression to moderate or severe OHSS requiring secondary care.
  • Provide reassurance that mild OHSS is usually self-limiting and resolves without invasive treatment.
  • Refer to secondary care if there is diagnostic uncertainty, severe symptoms, or complications such as significant ascites, electrolyte imbalance, or thromboembolism.

There is no specific pharmacological treatment recommended in primary care for mild OHSS; management is supportive and focused on symptom monitoring and prevention of progression.

Educational content only. Always verify information and use clinical judgement.