What are the potential complications of Hepatitis E that I should monitor in my patients?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Potential complications of hepatitis E to monitor in patients include:

  • Acute liver failure, especially in pregnant women and those with pre-existing liver disease.
  • Chronic hepatitis E infection, particularly in immunocompromised patients, which can lead to progressive liver fibrosis and cirrhosis.
  • Extrahepatic manifestations such as neurological complications (e.g., Guillain-Barré syndrome), renal injury, and pancreatitis.
  • Decompensation of underlying chronic liver disease.

Monitoring should focus on liver function tests, clinical signs of liver failure, and assessment for neurological or other systemic symptoms indicative of extrahepatic involvement.

Educational content only. Always verify information and use clinical judgement.