What are the current guidelines for the management of menopausal symptoms in primary care?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Offer hormone replacement therapy (HRT) to people with vasomotor symptoms associated with menopause, discussing the possible duration of treatment and reviewing benefits and risks at each review .

Consider menopause-specific cognitive behavioural therapy (CBT) as an option for vasomotor symptoms, either alongside HRT, if HRT is contraindicated, or if the person prefers not to take HRT .

Do not routinely offer SSRIs, SNRIs, or clonidine as first-line treatments for vasomotor symptoms alone .

For genitourinary symptoms, offer vaginal oestrogen, explaining that serious adverse effects are very rare, and review regularly; symptoms often return when stopped but treatment can be restarted .

When discussing vaginal oestrogen, involve shared decision-making about the formulation (cream, gel, tablet, pessary, or ring) and advise it can be used alone or with non-hormonal moisturisers or lubricants .

For those contraindicated for vaginal oestrogen or preferring non-hormonal options, consider non-hormonal vaginal moisturisers or lubricants, or vaginal prasterone if other treatments are ineffective or not tolerated .

Consider oral ospemifene for genitourinary symptoms if local treatments are impractical .

Provide information and support tailored to individual needs, including discussing menopause and management options with people and their families or carers .

Educational content only. Always verify information and use clinical judgement.