What initial assessments should I perform for an adult presenting with fever to determine the underlying cause?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Initial assessments for an adult presenting with fever to determine the underlying cause include:

  • Measure vital signs: temperature, heart rate, respiratory rate, blood pressure, oxygen saturation, and assess level of consciousness to identify severity and possible sepsis.
  • Examine for signs of sepsis or serious infection such as mottled or ashen appearance, cyanosis of skin, lips or tongue, non-blanching petechial or purpuric rash, breaches in skin integrity, or other rashes indicating infection.
  • Ask about recent fever or rigors and urinary output in the past 18 hours to assess systemic involvement and hydration status.
  • Consider the possibility of meningococcal disease or bacterial meningitis if there are signs such as non-blanching rash, neck stiffness, or altered consciousness, referring to specific NICE guidelines on these conditions.

These assessments help identify the underlying cause of fever and the presence of any life-threatening infections requiring urgent management .

Educational content only. Always verify information and use clinical judgement.