What are the recommended management strategies for a pregnant patient with a known history of von Willebrand disease?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For a pregnant patient with a known history of von Willebrand disease, the recommended management strategies include:

  • Plan birth in an obstetric-led unit with access to a neonatal unit capable of high-dependency care to manage potential bleeding risks for both mother and baby.
  • Active management of the third stage of labour is advised rather than physiological management to reduce the risk of postpartum haemorrhage.
  • Avoid intramuscular injections of uterotonics to minimise bleeding risk.
  • Individualised postpartum care should be arranged in consultation with a senior haematologist, including measurement of blood loss, monitoring for obstetric complications, and haematological parameters.
  • Inform the woman about the risk of secondary postpartum bleeding and how to access care after discharge.
  • Be cautious with the use of non-steroidal anti-inflammatory drugs as they can increase bleeding risk.

These strategies aim to reduce bleeding complications associated with von Willebrand disease during pregnancy, labour, and postpartum.

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