How should I approach the investigation of a patient with a first episode of ventricular tachycardia in the context of underlying heart disease?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025Updated: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Approach to investigating a first episode of ventricular tachycardia (VT) in a patient with underlying heart disease:

  • Urgent specialist cardiovascular assessment: Refer the patient urgently for specialist cardiovascular assessment, ideally within 24 hours, due to the high risk associated with VT and underlying structural heart disease .
  • Detailed clinical history and examination: Reassess the patient’s detailed history including any previous syncopal or arrhythmic events, family history of sudden cardiac death or inherited cardiac conditions, current medications, and perform a full cardiovascular examination including vital signs and lying/standing blood pressure if appropriate .
  • 12-lead ECG: Record and carefully interpret a 12-lead ECG to identify conduction abnormalities, QT interval abnormalities, ventricular arrhythmias, or other relevant changes .
  • Cardiac imaging: Perform cardiac imaging (e.g., echocardiography) to assess the extent and nature of structural heart disease, as this will guide further management and risk stratification .
  • Ambulatory ECG monitoring: Consider ambulatory ECG monitoring (Holter or event recorder) to detect arrhythmias and correlate symptoms, especially if VT is suspected to be intermittent .
  • Exclude other causes: Investigate for other potential causes or contributors such as electrolyte imbalances, ischemia, or drug effects .

This structured approach ensures timely diagnosis and management of VT in the context of underlying heart disease, reducing the risk of sudden cardiac death and guiding appropriate treatment.

Educational content only. Always verify information and use clinical judgement.