What are the key clinical features to consider when diagnosing thiamine deficiency in a patient presenting with neurological symptoms?

When diagnosing thiamine deficiency in a patient presenting with neurological symptoms, the key clinical features to consider are often associated with Wernicke encephalopathy NICE CG100. This condition is characterised by a classic triad of symptoms: altered mental state, oculomotor abnormalities, and ataxia NICE CG100. It is important to note that not all three features of this triad may be present simultaneously for a diagnosis of Wernicke encephalopathy NICE CG100. Thiamine deficiency, which can lead to Wernicke encephalopathy, is frequently observed in patients with alcohol use disorders Latt & Dore 2014. Therefore, a history of alcohol use disorder is a significant factor to consider in the diagnostic process Latt & Dore 2014.