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What pharmacological treatments are considered first-line for managing Social Anxiety Disorder?

Answer

Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 22 August 2025

For adults with Social Anxiety Disorder who decline cognitive behavioural interventions and express a preference for medication, the first-line pharmacological treatment is a selective serotonin reuptake inhibitor (SSRI) 1. Specifically, escitalopram or sertraline should be offered 1. Before prescribing any pharmacological intervention, it is important to discuss treatment options and any concerns the person has about taking medication 1. This discussion should include the likely benefits, potential side effects, discontinuation syndromes, drug interactions, and the risk of early activation symptoms with SSRIs (such as increased anxiety or agitation) 1. Patients should also be informed that the full anxiolytic effect develops gradually over two weeks or more, and that treatment should continue after remission to prevent relapse 1.

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