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How can I differentiate between a simple abscess and a more complicated skin infection that may require referral?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 22 August 2025
A simple abscess typically presents with localised signs of infection such as heat, redness, pain, and swelling 2. However, a skin infection or abscess may be considered more complicated and require referral if it presents with additional features or specific characteristics.
- Systemic signs of infection: The presence of fever or a raised white blood cell count, in addition to local signs, indicates a more serious infection 2.
- Cellulitis: If cellulitis is present, it suggests a spreading infection that requires antibiotic treatment 2.
- Size: While specifically mentioned for diverticular abscesses, abscesses greater than 3 cm may require interventions such as percutaneous drainage or surgery 3. This principle can be extended to large cutaneous abscesses.
- Lack of clinical improvement or deterioration: If an abscess does not improve clinically or deteriorates despite initial management, further assessment or re-imaging may be necessary 3.
- Specific severe skin conditions: Conditions like acne fulminans require urgent same-day referral to an on-call hospital dermatology team 1. Acne conglobata or nodulo-cystic acne also warrant referral to a consultant dermatologist-led team 1.
- Diagnostic uncertainty: If there is uncertainty about the diagnosis of the skin condition, referral to a consultant dermatologist-led team is recommended 1.
- Failure of treatment: Moderate to severe acne that has not responded to previous treatment, particularly if it included an oral antibiotic, is a reason to consider referral 1. This principle can be applied to other skin infections failing to respond to appropriate treatment.
- Need for microbiological guidance: Samples of pus from a drained abscess should be sent to microbiology to tailor antibiotic treatment based on sensitivities 3.
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