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What are the key features to identify in an ECG that suggest acute myocardial infarction?

Answer

Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 21 August 2025

To identify an acute myocardial infarction (MI) on an electrocardiogram (ECG), key features include:

  • Regional ST-segment elevation or presumed new left bundle branch block (LBBB) are consistent with an acute ST-segment elevation myocardial infarction (STEMI) 1. These findings immediately prompt assessment for coronary reperfusion therapy 2.
  • Regional ST-segment depression or deep T wave inversion are suggestive of a non-ST-segment elevation myocardial infarction (NSTEMI) or unstable angina 1.
  • Even in the absence of ST-segment changes, an increased suspicion of an acute coronary syndrome (ACS) should be maintained if there are other changes such as Q waves and T wave changes 1.
  • It is important to note that a normal resting 12-lead ECG does not exclude an ACS 1.
  • If the diagnosis of ACS is in doubt, healthcare professionals should consider taking serial resting 12-lead ECGs, reviewing previous ECGs, and recording additional ECG leads 1. The 12-lead ECG is a crucial tool for diagnosing acute myocardial infarction in the emergency department (Miranda et al., 2018).
  • ECG interpretation should be reviewed by a healthcare professional qualified to interpret them, while also taking into account automated interpretation 1.

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This content was generated by iatroX. Always verify information and use clinical judgment.