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What are the potential complications of TTP that I should monitor for in my patients?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 17 August 2025
When monitoring patients with thrombotic thrombocytopenic purpura (TTP), it is crucial to be vigilant for several potential complications.
- Neurological complications are significant, including the risk of stroke and transient ischaemic attack (TIA) 4,8.
- Patients may also experience cardiac implications due to TTP (Wiernek et al., 2018).
- Given the thrombotic nature of the condition, monitoring for thrombotic events such as deep vein thrombosis (DVT) is important 6.
- Furthermore, TTP can have significant long-term clinical impacts, including the potential for disease relapse (Tran et al., 2025).
- Rapid deterioration requiring emergency management is also a concern (Long et al., 2021).
Key References
- NG121 - Intrapartum care for women with existing medical conditions or obstetric complications and their babies
- CKS - Hyperthyroidism
- CKS - Platelets - abnormal counts and cancer
- CKS - Stroke and TIA
- NG24 - Blood transfusion
- CKS - Deep vein thrombosis
- NG137 - Twin and triplet pregnancy
- NG128 - Stroke and transient ischaemic attack in over 16s: diagnosis and initial management
- (Wiernek et al., 2018): Cardiac implications of thrombotic thrombocytopenic purpura.
- (Long et al., 2021): Evaluation and Management of Thrombotic Thrombocytopenic Purpura in the Emergency Department.
- (Tran et al., 2025): Relapse and beyond: Navigating the long-term clinical impacts of immune thrombotic thrombocytopenic purpura.
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