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What are the key clinical features to consider when diagnosing silicosis in a patient with a history of occupational exposure?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 17 August 2025
When diagnosing silicosis in a patient with a history of occupational exposure, a detailed occupational history, specifically regarding silica exposure, is a primary consideration (Hoy and Chambers, 2020). A crucial clinical feature to consider is the strong association between silicosis and tuberculosis (Rees and Murray, 2007). Therefore, the presence of symptoms suggestive of tuberculosis, such as chronic cough, fever, night sweats, or unexplained weight loss, should prompt investigation in patients with suspected silicosis (Rees and Murray, 2007). Silicosis is recognised as a significant silica-related disease (Hoy and Chambers, 2020).
Key References
- CG163 - Idiopathic pulmonary fibrosis in adults: diagnosis and management
- NG12 - Suspected cancer: recognition and referral
- CKS - Lung and pleural cancers - recognition and referral
- CKS - Chronic obstructive pulmonary disease
- CKS - Palliative care - cough
- CKS - Sarcoidosis
- NG115 - Chronic obstructive pulmonary disease in over 16s: diagnosis and management
- (Rees and Murray, 2007): Silica, silicosis and tuberculosis.
- (Hoy and Chambers, 2020): Silica-related diseases in the modern world.
- (Hua et al., 2023): Pathology and Mineralogy of the Pneumoconioses.
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