When should I consider referring a patient with pseudogout to a rheumatologist for further evaluation and management?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 17 August 2025Updated: 17 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

When considering referring a patient with pseudogout to a rheumatologist for further evaluation and management, you should consider referral if the diagnosis of the joint condition remains uncertain ,. Referral is also appropriate for any adult with suspected persistent synovitis of undetermined cause ,.

It is crucial to assess the possibility of septic arthritis, calcium pyrophosphate crystal deposition (pseudogout), and inflammatory arthritis in people presenting with a painful, red, swollen joint . If septic arthritis is suspected, immediate referral according to the local care pathway is necessary .

While specific referral criteria for pseudogout are not detailed in the provided guidelines as they are for gout, the general principles for uncertain diagnosis and persistent inflammatory conditions apply ,,,. It is noted that if acute calcium pyrophosphate (CPP) arthritis ('pseudogout') is suspected, it may not follow the urgent referral pathway for new-onset inflammatory arthritis for spondyloarthritis assessment .

Educational content only. Always verify information and use clinical judgement.