What are the recommended management strategies for a patient diagnosed with a complete molar pregnancy?

For a patient diagnosed with a complete molar pregnancy, the primary recommended management strategy involves the evacuation of the mole ¹. This procedure is typically performed via suction curettage ¹.

Following the evacuation, meticulous follow-up is essential due to the significant risk of developing gestational trophoblastic neoplasia (GTN) [1, (Seckl et al., 2010)]. This follow-up primarily involves the serial monitoring of human chorionic gonadotropin (hCG) levels [1, (Seckl et al., 2010)]. hCG levels should be monitored until they return to normal and then for a specified period to detect any persistent trophoblastic disease [1, (Seckl et al., 2010)]. Gestational trophoblastic neoplasia develops in approximately 15-20% of cases of complete moles and often requires chemotherapy for treatment [ (Seckl et al., 2010)].

Regarding prophylactic measures, some literature explores the use of prophylactic chemotherapy for hydatidiform mole with the aim of preventing gestational trophoblastic neoplasia (GTN) [ (Wang et al., 2017)].