What follow-up care is recommended for patients who have been treated for malaria to monitor for potential complications?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Follow-up care for patients treated for malaria involves clinical and parasitological monitoring to detect potential complications and relapses.

  • Patients treated for falciparum malaria should be admitted for at least 24 hours to ensure treatment tolerance and effective reduction of parasitaemia, allowing rapid intervention if deterioration occurs.
  • Outpatient management may be considered only if daily clinical and parasitological monitoring is available until infection clearance, especially for uncomplicated non-falciparum malaria.
  • Patients should be advised to report any recurrence of symptoms such as fever, as relapses can occur due to treatment failure or drug resistance.
  • Blood tests are required after treatment with intravenous artesunate to monitor for haemolysis, a known complication.
  • Pregnant women and children require close monitoring due to higher risk of complications; neonates born to mothers with malaria should be screened at birth and weekly up to 28 days.
  • All cases must be notified to public health authorities for surveillance.
  • Patients should be informed about the risk of future malaria episodes and advised on preventive measures and chemoprophylaxis for future travel.

In summary, follow-up includes clinical observation, parasitological testing, monitoring for haemolysis if artesunate was used, vigilance for relapse symptoms, and public health notification.

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