What monitoring protocols should be followed for a patient receiving treatment for hypernatraemia?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Monitoring protocols for a patient receiving treatment for hypernatraemia include:

  • Measure plasma electrolyte concentrations every 4 to 6 hours during the first 24 hours of treatment, then adjust the frequency of monitoring based on the patient's response to treatment.
  • Ensure that the rate of fall of plasma sodium does not exceed 12 mmol/l in a 24-hour period to avoid complications.
  • Regularly assess fluid status and adjust intravenous fluid prescriptions accordingly, including consideration of changing to hypotonic fluids if hypernatraemia worsens or remains unchanged after initial treatment.
  • Monitor clinical response closely, including signs of dehydration or fluid overload, and reassess fluid management plans if the patient is transferred to a different care setting.

These steps help safely correct hypernatraemia while minimizing risks associated with rapid sodium changes and fluid mismanagement.

References:

Educational content only. Always verify information and use clinical judgement.