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What are the recommended first-line treatments for patients diagnosed with dry eye syndrome in primary care?
Answer
Guideline-Aligned (High Confidence)
Generated by iatroX. Developer: Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner).
Last reviewed: 16 August 2025
For patients diagnosed with dry eye syndrome in primary care, the recommended first-line treatments involve a stepped approach, beginning with lifestyle measures, followed by the use of tear substitutes if symptoms persist 1.
- Lifestyle Measures: Patients should be advised on lifestyle modifications for symptom relief 1. This includes using warm compresses, practicing lid hygiene, and performing lid massage, particularly if blepharitis or Meibomian gland dysfunction is present 1. Other recommendations include modifying contact lens wear, using moisture chamber eyewear (such as wrap-around glasses or specialist goggles), and adjusting environmental factors like increasing humidity, avoiding prolonged digital device use, and lowering computer screens 1.
- Tear Substitutes ('Artificial Tears'): If lifestyle measures are insufficient for symptom relief, tear substitutes are advised 1. People with mild-to-moderate dry eye symptoms should self-manage using over-the-counter topical preparations 1. A wide range of tear substitutes are available over-the-counter in various formulations, including eye drops, gels, ointments, and sprays 1. Low-viscosity drops are typically recommended for daytime use to reduce the risk of adverse effects like blurred vision, while increased viscosity ointments or gels may be needed for overnight use 1. Examples of options include hypromellose and carbomers 1. Where possible, preservative-free topical formulations should be advised, especially if the person is intolerant of preservatives, has moderate-to-severe dry eye requiring topical preparations more than four times per day, is using multiple topical eye preparations, or uses soft or hybrid contact lenses 1.
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