What are the recommended first-line treatments for managing blepharitis in adults?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The recommended first-line treatments for managing blepharitis in adults primarily focus on conservative measures and managing associated conditions .

  • Eyelid Hygiene and Warm Compresses: Eyelid hygiene is considered the mainstay of treatment . Patients should be advised to wet a cloth or cotton bud with a cleanser (e.g., baby shampoo diluted 1:10 with warm water, sodium bicarbonate solution, or manufactured lid cleansing products) and gently wipe along the lid margins to clear debris . This should be done twice daily initially, then once daily as symptoms improve . A warm compress, such as a clean flannel rinsed with warm water, should be applied to closed eyelids for 5–10 minutes once or twice daily . For posterior blepharitis, eyelid massage can be performed after applying the warm compress, gently massaging the area in the direction of the eyelashes to express meibomian gland content . Patients should be educated on the chronic nature of blepharitis and the importance of continuing conservative treatment, especially eyelid hygiene, even when symptoms are well controlled, to minimise relapses . They should also avoid eye makeup, particularly eyeliner and mascara, during exacerbations .
  • Managing Associated Conditions: Treatment of any associated or underlying medical conditions, such as dry eye disease, seborrhoeic dermatitis, or rosacea, is essential for successful management .
  • Topical Antibiotics: If eyelid measures are ineffective for anterior blepharitis, a topical antibiotic such as chloramphenicol can be considered . This can be rubbed into the lid margin, typically twice daily . Treatment duration is usually a few weeks until acute symptoms resolve .

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