What are the key clinical features and symptoms that should raise susp

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In a primary care setting, several key clinical features and symptoms should raise suspicion for leukaemia, which includes Acute Myeloid Leukaemia (AML), prompting further investigation ,. The recommendations differ slightly for adults compared to children and young people ,.

For adults, consider a very urgent full blood count (within 48 hours) if they present with any of the following:

Pallor ,
Persistent fatigue
Unexplained fever ,
Unexplained persistent or recurrent infection ,
Generalized lymphadenopathy
Unexplained bruising ,
Unexplained bleeding
Unexplained petechiae
Hepatosplenomegaly

For children and young people, the following symptoms should prompt action:

Refer for immediate specialist assessment if they have unexplained petechiae or hepatosplenomegaly ,.
Offer a very urgent full blood count (within 48 hours) if they present with any of the following:

Pallor ,
Persistent fatigue ,
Unexplained fever ,
Unexplained persistent infection ,
Generalized lymphadenopathy ,
Persistent or unexplained bone pain
Unexplained bruising ,,
Unexplained bleeding

What are the key clinical features and symptoms that should raise suspicion for Acute Myeloid Leukaemia (AML) in a primary care setting?

Key References

What are the key clinical features and symptoms that should raise suspicion for Acute Myeloid Leukaemia (AML) in a primary care setting?

Key References

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