How should I differentiate between testicular torsion and epididymitis in a patient presenting with acute scrotal pain?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 16 August 2025Updated: 16 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Differentiating between testicular torsion and epididymitis in a patient presenting with acute scrotal pain is critical due to the emergency nature of testicular torsion .

Testicular Torsion:

  • It is typically characterised by sudden-onset scrotal pain .
  • Testicular torsion is a urological emergency, and if clinically suspected, immediate surgical exploration is necessary .
  • If testicular torsion is suspected, the patient requires emergency hospital admission to urology or paediatric surgery .
  • Surgical repair should ideally be performed within 4 hours to salvage the testicle .
  • A history of previous episodes of severe, self-limiting scrotal pain or swelling may indicate spontaneous testicular torsion and detorsion, which warrants a urology referral .

Epididymitis:

  • If an adolescent or adult has suspected epididymo-orchitis, emergency hospital admission is arranged if symptoms are severe, the person is systemically unwell, or there is a suspected serious complication .
  • Serious complications that may require urgent ultrasound and/or hospital admission include testicular abscess or infarction .
  • If hospital admission is not needed, management involves identifying the most likely causative organism based on the person's age, urine dipstick results, and risk factors .
  • This may involve assessing the risk of a sexually transmitted infection (STI) or an enteric organism associated with a lower urinary tract infection (UTI) .
  • If an STI is the most likely cause, urgent referral to a local specialist sexual health clinic is advised for testing, treatment, and possible contact tracing .
  • If an enteric organism is the most likely cause, a urine dipstick test and mid-stream urine (MSU) sample for microscopy and culture should be arranged, and empirical antibiotic treatment may be considered .

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