Which imaging modalities are recommended for evaluating knee pain in primary care, and when should I refer for further investigation?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025Updated: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

For evaluating knee pain in primary care, imaging modalities are generally not routinely recommended for diagnosis or management of osteoarthritis (OA) unless specific criteria are met .

  • Diagnosis of Osteoarthritis: OA can typically be diagnosed clinically without imaging in individuals aged 45 or over who have activity-related joint pain and morning stiffness lasting no longer than 30 minutes . Imaging should not be routinely used for diagnosis unless there are atypical features or signs suggesting an alternative or additional diagnosis .
  • Management of Osteoarthritis: Imaging is not routinely used for follow-up or to guide non-surgical management of OA .
  • Sprains and Strains: Magnetic Resonance Imaging (MRI) is considered the gold standard for imaging ligamentous and intra-articular structures of the knee . However, its routine use for acute injuries is limited by cost and availability . MRI should be reserved for cases of persistent symptoms in severe sprains or chronic instability to rule out osteochondral defects, missed syndesmotic injuries, or bony injuries not identified on X-ray .
  • Specialised Assessment: Appropriately focused imaging for knee pain is in most cases better performed as part of further specialised assessment . Direct access to MRI may be available depending on local arrangements and criteria .

You should refer a patient for further investigation under the following circumstances:

  • Urgent Referral (to be seen within 2 weeks):
    • If a tumour is suspected ,.
    • If persistent synovitis of undetermined cause is suspected, especially if small joints of the hand or feet are affected, more than one joint is affected, or there has been a delay of 3 months or longer between symptom onset and seeking medical help . Refer urgently to a rheumatologist to assess for inflammatory polyarthritis .
    • If a child or young person presents with suspected juvenile idiopathic arthritis, refer urgently to a paediatric rheumatologist and discuss immediate management with the on-call rheumatologist .
    • If osteonecrosis of the knee is suspected, refer urgently to an orthopaedic surgeon .
  • Immediate Assessment:
    • If patellar dislocation occurs in a person with recurrent dislocation and is associated with moderate or severe swelling .
    • If Henoch-Schönlein purpura is suspected .
    • If a child presents with a limp .
  • Referral for Further Assessment and/or Advice (to an integrated musculoskeletal service or orthopaedic surgeon):
    • Persisting knee pain or other symptoms for more than six weeks .
    • A suspected degenerative meniscal tear .
    • Symptomatic bipartite patella .
    • Fat pad impingement/inflammation .
    • Plicae syndrome .
    • Osteochondritis dissecans .
    • Recurrent patellar dislocation/subluxation .
    • Patellofemoral pain syndrome, particularly if not improved after 6 weeks of conservative management .
    • Iliotibial band syndrome .
  • Other Specific Referrals:
    • If complex regional pain syndrome is suspected, refer to an appropriate specialist for confirmation of diagnosis, to rule out ongoing pathology, and for symptom control and rehabilitation .
    • If the diagnosis is uncertain, consider referring to an appropriate specialist (e.g., rheumatologist, orthopaedic surgeon, sports physician, or other musculoskeletal specialist) .
    • For osteoarthritis, consider referral to an orthopaedic surgeon if non-surgical management is unsuitable or ineffective after 3 months, especially if symptoms substantially impact the person's quality of life, there is diagnostic uncertainty or atypical features, or a sudden worsening of symptoms . The decision to refer for joint surgery should not be based on age, sex, smoking status, comorbidities, or BMI ,.

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